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LIPEX™ Extruder
The LIPEX™ Extruder was introduced by LIPEX Biomembranes in 1985, and quickly became the industry standard for the preparation of laboratory-scale liposome formulations. The 10 mL small-scale unit was supplemented with 100 and 800 mL units to facilitate scale-up and GMP production of early-stage clinical products. Stand-alone filter holders (142 and 293 mm) were later introduced to support large-scale batch preparation under cGMP using nitrogen pressure or pharmaceutical-grade pumps.
The LIPEX™ EXTRUDERS are designed to generate homogeneous populations of unilamellar vesicles (liposomes) without the need for solvents or detergents. Extrusion is a quick and simple one-step procedure that produces liposomes by forcing aqueous suspensions of lipid through polycarbonate filters with defined pore size. It is relatively gentle, exposing the formulation to moderate pressures (100 – 700 psi) at controlled temperatures which contrasts with homogenization where temperature may fluctuate, and pressures often exceed 18,000 psi. The LIPEX Extruder offers a number of advantages over alternative lipid manufacturing strategies;
- Extruders are reliable, have no moving parts, and are made from high grade stainless steel.
- Particle size is homogeneous, and readily controlled.
- High trapping efficiencies are achieved.
- A wide variety of lipid compositions may be utilized.
- There are no product volume restrictions.
- Operating costs are low and equipment is easy to use.
An ever-expanding customer base has made LIPEX™ technology the equipment of choice that provides seamless scale-up from research to clinical manufacturing.
Additional Information on Extruders
Extruders & Spares 2007 ( PDF 148KB)
Extruder Assembly and Operating Manual (PDF 393KB)
Customized Extruder Questionnaire (PDF 179KB)
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